Heavy rain has caused the partial closure of the West Coast mainline after flooding between England and Scotland.
Network Rail said water levels were about a foot above the northbound track between Penrith North Lakes and Lockerbie, resulting in its closure.
The company said passengers on five trains were currently trapped or blocked by flood waters.
They warned services were likely to be affected until the end of the day.
It comes amid fresh Met Office warnings of rain and thunderstorms across the UK.
Customers travelling between Carlisle and Glasgow Central/Edinburgh are being advised not to travel.
The issue is also affecting the wider network with companies including Virgin Trains, LNER and CrossCountry urging passengers to check ahead.
Network Rail said northbound trains would head back towards Carlisle.
It said inspections indicated that water levels on the southbound track were not as bad as those northbound and that the southbound line would be reopened with a 5mph speed limit.
In Wales, more than 1,200 households have been left without power after windy weather caused disruption.
The worst affected area was around Ebbw Vale in Blaenau Gwent where almost 700 customers lost power and Glynneath in Neath Port Talbot where more than 300 homes were cut-off.
The Scottish Environment Protection Agency has also issued 14 flood alerts across Tayside, the east, west, central and southern Scotland.
Heavy rain has also caused flooding for road users on the A74 in Dumfriesshire.
The issue resulted in long delays at Eaglesfield after two lanes were closed southbound on the route as a result of flooding.
In Renfrewshire, engineers worked to repair overhead wires that had left 200 passengers stranded on three trains on Friday.
The loss of power had impacted on services through Bishopton.
Network Rail said services were gradually being reintroduced to the line on Saturday after engineers worked through the night to reopen the tunnel between Langbank and Bishopton.
On Friday, organisers of cycling’s Women’s Tour of Scotland, taking place for the first time, were forced to abandon the first stage of the event – from Dundee to Dunfermline – due to “extreme weather conditions”.
Stage two of the event – from Glasgow to Perth – was to due start on Saturday.
Forecaster Craig Snell said heavy rain was affecting the northern border areas of England into Scotland, with further showers expected in the north as heavy and slow-moving thunderstorms roll through.
Mr Snell said: “No matter where you are in the UK, you’re at risk of seeing some kind of localised disruption from wind.
“It’s a case of staying in touch with weather forecasts and being prepared for extra travel time as there may be road closures due to localised flooding.”